TY  - JOUR
A1  - Busse, E.
T1  - Wirkung von Glia-Maturationsfaktor (GMF) und Adhäsionsfaktor (ADF) auf Kulturen leukämischer Zellen
T1  - Effect of Glia Maturation Factor (GMF) and Adhesion Factor (ADF) on Cultures of Leukaemic Cells
T2  - Zeitschrift für Naturforschung, B
N2  - GMF was isolated from the glia of different brain parts of calf. Its influence on the input of 3H-TdR was tested in leukaemic and non-malignant lymphocites. GMF isolated from the diencephalon proved to be the most effective one. The used substance of reference was DBcAMP. The cAMP contents of leukaemic cells were lower than those of non-malignant cells, whereas the level of cGMP was higher in the first ones. We found both in non-malignant cultures and in cultures of leukaemic cells that the impact of GMF and AdF elevated the cAMP value and reduced cGMP. The adhesion of cAMP to the nuclei of leukaemic was reduced in comparison with non-malignant cells. The nuclei of leukaemic cells showed increased adhesive capacity after pre-incubation with GMF and AdF. The adhesive capacity of non-malignant nuclei remained unchanged. The adenylcyclase activity (AC) was diminished in leukaemic cells. It could not be stimulated by means of catecholamines. GMF and AdF produced a slight increase of the basal Ac activity in cultures of leukaemic cells only. But isoproterenol led to a distinct increase of the Ac activity in leukaemic cells when incubation with those two factors preceded it.
KW  - Glia Maturation Factor
KW  - Adhesion Factor
KW  - Leukaemic Cells
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/71433
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-714333
SN  - 1865-7117
SN  - 0932-0776
VL  - 42.1987
IS  - 11
SP  - 1481
EP  - 1486
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -