TY  - JOUR
A1  - Kazimierczuk, Zygmunt
A1  - Stolarski, Ryszard
A1  - Shugar, David
T1  - Stereospecific synthesis by the sodium salt glycosylation method of halogeno benzimidazole 2'-deoxyribose analogues of the inhibitor of hnRNA synthesis, 5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (DRB)
T2  - Zeitschrift für Naturforschung, C
N2  - The recently developed stereospecific sodium salt glycosylation procedure has been successfully applied to the synthesis of the β-ᴅ-2′-deoxyribofuranosides of benzimidazole, 5,6-dihalogeno benzimidazoles, and some 2-substituted analogues in high yield. The 5,6-dibromo analogue was obtained by bromination of the parent nucleoside. These have all been characterized by spectro­scopic methods, including 1H NMR, which permitted analyses of their solution conformations and comparison with those of the corresponding ribofuranosides. Some biological aspects, including preliminary results on cytotoxicity and antiviral activity, are briefly considered.
KW  - Halogenobenzimidazoles
KW  - β-ᴅ-2′-Deoxyribosides
KW  - Specific Synthesis
KW  - 1H NMR; Conformational Properties
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81790
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-817908
SN  - 0939-5075
SN  - 1865-7125
VL  - 40.1985
IS  - 9-10
SP  - 715
EP  - 720
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -