TY  - JOUR
A1  - Zöllner, Johann Philipp
A1  - Wichert, Jennifer
A1  - Schubert-Bast, Susanne
A1  - Hattingen, Elke
A1  - Rosenow, Felix
A1  - Strzelczyk, Adam
T1  - Local glucose metabolism is unaltered in reversible splenial lesion syndrome
T2  - European journal of neurology
N2  - Background and purpose: Transient splenial oedema, also known as reversible splenial lesion syndrome (RESLES), is a rare magnetic resonance imaging (MRI) finding that presents as a round or ovoid focal oedema in the posterior corpus callosum, and is associated with a wide range of clinical conditions. The aetiology of RESLES is not fully clear. We aimed to investigate conflicting pathophysiological hypotheses by measuring local glucose metabolism in patients with RESLES.
Methods: We retrospectively analysed patients with RESLES after reductions in antiseizure medications during in-hospital video electroencephalography monitoring. We measured local glucose uptake using positron emission tomography/computed tomography and compared matched cohorts of patients with and without MRI evidence of RESLES using nonparametric tests.
Results: Local glucose metabolism in the splenium of seven patients with RESLES was not significantly different from the glucose metabolism of the seven patients in the matched cohort. This was true using both regular and normalized standardized glucose uptake value calculation methods (p = 0.902 and p = 0.535, respectively).
Conclusion: We found no evidence of local glucose hypometabolism in RESLES, which supports previous pathophysiological considerations that suggest that RESLES is an intercellular, intramyelinic oedema rather than a typical intracellular cytotoxic oedema, which is not reversible.
KW  - CLOCC
KW  - corpus callosum
KW  - DWI
KW  - encephalopathy
KW  - oedema
KW  - RESLES
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75614
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-756148
SN  - 1468-1331
N1  - This study was supported by a LOEWE Grant from the State of Hessen for the “Center for Personalized Translational Epilepsy Research” (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Open access funding enabled and organized by ProjektDEAL.
VL  - 29
IS  - 6
SP  - 1836
EP  - 1840
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -