TY  - JOUR
A1  - Cosgarea, Raluca
A1  - Eick, Sigrun
A1  - Batori-Andronescu, Ionela
A1  - Jepsen, Søren
A1  - Arweiler, Nicole B.
A1  - Rößler, Ralf
A1  - Conrad, Torsten
A1  - Ramseier, Christoph A.
A1  - Sculean, Anton
T1  - Clinical and microbiological evaluation of local doxycycline and antimicrobial photodynamic therapy during supportive periodontal therapy: a randomized clinical trial
T2  - Antibiotics
N2  - The aim of this study was to evaluate the clinical and microbiological effects of subgingival instrumentation (SI) alone or combined with either local drug delivery (LDD) or photodynamic therapy (PDT) in persistent/recurrent pockets in patients enrolled in supportive periodontal therapy (SPT). A total of 105 patients enrolled in SPT were randomly treated as follows: group A (n = 35): SI +PDT and 7 days later 2nd PDT; group B (n = 35): SI+LDD; group C (n = 35): SI (control). Prior intervention, at 3 and 6 months after therapy, probing pocket depths, clinical attachment level, number of treated sites with bleeding on probing (n BOP), full mouth plaque and bleeding scores (gingival bleeding index, %BOP) were recorded. At the same time points, 8 periodontopathogens were quantitatively determined. All three treatments resulted in statistically significant improvements (p < 0.05) of all clinical parameters without statistically significant intergroup differences (p > 0.05). Several bacterial species were reduced in both test groups, with statistically significantly higher reductions for LDD compared to PDT and the control group. In conclusion, the present data indicate that: (a) In periodontal patients enrolled in SPT, treatment of persistent/recurrent pockets with SI alone or combined with either PDT or LDD may lead to comparable clinical improvements and (b) the adjunctive use of LDD appears to provide better microbiological improvements for some periodontal pathogens than SI alone or combined with PDT.
KW  - supportive periodontal therapy
KW  - photodynamic therapy
KW  - local drug delivery
KW  - periodontal treatment
KW  - persistent periodontal pockets
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62143
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621432
SN  - 2079-6382
N1  - The Company Bredent GmbH (Senden, Germany) supported the study by providing material for PDT and financial support for the microbiological analysis.
VL  - 10
IS  - 3, art. 277
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -