TY  - JOUR
A1  - El-Battrawy, Ibrahim
A1  - Erath-Honold, Julia
A1  - Vamos, Mate
A1  - Aweimer, Assem
A1  - Mügge, Andreas
A1  - Lang, Siegfried
A1  - Ansari, Uzair
A1  - Gietzen, Thorsten
A1  - Akin, Ibrahim
T1  - A case series of concomitant cardiac electrical disease among Takotsubo syndrome patients and literature eview
T2  - Journal of cardiovascular development and disease
N2  - The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended.
KW  - Takotsubo Syndrome
KW  - acquired LQT syndrome
KW  - catecholamine excess
KW  - mortality
KW  - estrogen
KW  - beta-blocker
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83372
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-833727
SN  - 2308-3425
VL  - 9
IS  - 3, art. 79
SP  - 1
EP  - 9
PB  - MDPI AG
CY  - Basel
ER  -