TY  - JOUR
A1  - Proschek, Dirk
A1  - Tonak, Marcus
A1  - Zangos, Stephan
A1  - Mack, Martin G.
A1  - Kurth, Andreas Alois
T1  - Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
T2  - Journal of bone oncology
N2  - Background: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape.
Material and methods: VX-2 tumor was used for the induction of experimental bone metastases in the femur of six New Zealand white rabbits. X-ray imaging as well as CT and MRI scans before and after treatment was carried out. After detecting bone tumor, radiofrequency ablation was performed. The ablation instrument contained a 10 g bipolar, articulated extendable electrode and a proprietary generator with an impedance controlled algorithm. All bones and the soft tissue were examined histologically.
Results: All animals developed local bone tumor. Mean duration until first osteolytic lesions on CT-scans was 48±14 days. The mean lesion area was 26 mm(2). No systemic tumor spread was seen. 6 radiofrequency procedures were carried out with a mean application time of 6 min±2:30 and an average temperature in the region of effect of 55 °C±4. MRI imaging demonstrated an ablation zone of 23±6 mm around the electrode. Histopathology showed an extensive heat necrosis with no remaining tumor cells in the ablation area.
Conclusion: Radiofrequency ablation is a quickly developing treatment option on the field of minimal invasive bone tumor therapy. The electrode enables an ablation adapted to size and shape of the metastases. Further clinical studies are necessary to test and enhance this radiofrequency system.
KW  - Radiofrequency ablation
KW  - Bone tumor
KW  - Animal model
KW  - Rabbit
KW  - VX-2
KW  - Tumor therapy
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76699
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-766996
SN  - 2212-1374
VL  - 1
IS  - 2
SP  - 63
EP  - 66
PB  - Elsevier
CY  - Amsterdam
ER  -