TY  - JOUR
A1  - Leppik, Liudmila
A1  - Costa Oliveira, Karla Mychellyne
A1  - Bhavsar, Mit Balvantray
A1  - Barker, John Howard
T1  - Electrical stimulation in bone tissue engineering treatments
T2  - European journal of trauma and emergency surgery
N2  - Electrical stimulation (EStim) has been shown to promote bone healing and regeneration both in animal experiments and clinical treatments. Therefore, incorporating EStim into promising new bone tissue engineering (BTE) therapies is a logical next step. The goal of current BTE research is to develop combinations of cells, scaffolds, and chemical and physical stimuli that optimize treatment outcomes. Recent studies demonstrating EStim’s positive osteogenic effects at the cellular and molecular level provide intriguing clues to the underlying mechanisms by which it promotes bone healing. In this review, we discuss results of recent in vitro and in vivo research focused on using EStim to promote bone healing and regeneration and consider possible strategies for its application to improve outcomes in BTE treatments. Technical aspects of exposing cells and tissues to EStim in in vitro and in vivo model systems are also discussed.
KW  - Electrical stimulation
KW  - Bone regeneration
KW  - Bone tissue engineering
KW  - In vitro
KW  - In vivo
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63725
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637259
SN  - 1863-9941
N1  - Open Access funding provided by Projekt DEAL.
N1  - This study was supported by the Friedrichsheim Foundation (Stiftung Friedrichsheim) based in Frankfurt/Main, Germany.
VL  - 46
IS  - 2
SP  - 231
EP  - 244
PB  - Springer Medizin
CY  - Heidelberg
ER  -