TY  - JOUR
A1  - Mertens, Christina
A1  - Marques, Oriana
A1  - Horvat, Natalie
A1  - Simonetti, Manuela
A1  - Muckenthaler, Martina
A1  - Jung, Michaela
T1  - The macrophage iron signature in health and disease
T2  - International journal of molecular sciences
N2  - Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external stimuli. This in turn polarizes macrophages into a broad spectrum of functional activation states, also reflected in their iron-regulated gene profile. The fast adaptation to the environment in which they are located helps to maintain tissue homeostasis under physiological conditions.
KW  - macrophage polarization
KW  - iron metabolism
KW  - disordered iron metabolism
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62634
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-626342
SN  - 1422-0067
N1  - This research was funded by Wilhelm Sander-Stiftung (2017.130.2, awarded to M.J.). O.M.was supported by a Junior Research Grant from the European Hematology Association O.M. (EHA:RG-70).
VL  - 22
IS  - 16, art. 8457
SP  - 1
EP  - 30
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -