TY  - JOUR
A1  - Rogala, Sandra
A1  - Ali, Tamer
A1  - Melissari, Maria-Theodora
A1  - Währisch, Sandra
A1  - Schuster, Peggy
A1  - Sarre, Alexandre
A1  - Emídio, Rebeca Cordellini
A1  - Böttger, Thomas
A1  - Rogg, Eva-Maria Pia
A1  - Kaur, Jaskiran
A1  - Krishnan, Jaya
A1  - Dumbović, Gabrijela
A1  - Dimmeler, Stefanie
A1  - Ounzain, Samir
A1  - Pedrazzini, Thierry
A1  - Herrmann, Bernhard
A1  - Grote, Phillip
T1  - The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males
T2  - Nature Communications
N2  - After myocardial infarction in the adult heart the remaining, non-infarcted tissue adapts to compensate the loss of functional tissue. This adaptation requires changes in gene expression networks, which are mostly controlled by transcription regulating proteins. Long non-coding transcripts (lncRNAs) are taking part in fine-tuning such gene programs. We describe and characterize the cardiomyocyte specific lncRNA Sweetheart RNA (Swhtr), an approximately 10 kb long transcript divergently expressed from the cardiac core transcription factor coding gene Nkx2-5. We show that Swhtr is dispensable for normal heart development and function but becomes essential for the tissue adaptation process after myocardial infarction in murine males. Re-expressing Swhtr from an exogenous locus rescues the Swhtr null phenotype. Genes that depend on Swhtr after cardiac stress are significantly occupied and therefore most likely regulated by NKX2-5. The Swhtr transcript interacts with NKX2-5 and disperses upon hypoxic stress in cardiomyocytes, indicating an auxiliary role of Swhtr for NKX2-5 function in tissue adaptation after myocardial injury.
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/85565
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-855653
SN  - 2041-1723
VL  - 14
IS  - article number: 7024
PB  - Nature Publishing Group UK
CY  - London
ER  -