TY  - JOUR
A1  - Xie, Hui
A1  - Chun, Felix
A1  - Rutz, Jochen
A1  - Blaheta, Roman A.
T1  - Sulforaphane impact on reactive oxygen species (ROS) in bladder carcinoma
T2  - International journal of molecular sciences
N2  - Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
KW  - bladder cancer
KW  - sulforaphane
KW  - ROS
KW  - oxidative stress
KW  - Keap1-Nrf2
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62488
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-624882
SN  - 1422-0067
N1  - This work was supported by the Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany, and the China Scholarship Council No. 201707660003.
VL  - 22
IS  - 11, art. 5938
SP  - 1
EP  - 19
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -