TY  - JOUR
A1  - Nicin, Luka
A1  - Wagner, Julian Uwe Gabriel
A1  - Luxán, Guillermo
A1  - Dimmeler, Stefanie
T1  - Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart
T2  - FEBS letters
N2  - Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single-cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes.
KW  - aging
KW  - cardiomyocytes
KW  - cardiovascular disease
KW  - electrical coupling
KW  - endothelial cells
KW  - exosomes
KW  - fibroblasts
KW  - heart
KW  - immune cells
KW  - paracrine signaling
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75213
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-752132
SN  - 1873-3468
VL  - 596
IS  - 5
SP  - 638
EP  - 654
PB  - Wiley
CY  - Chichester
ER  -