TY  - JOUR
A1  - Yuan, Ting
A1  - Krishnan, Jaya
T1  - Non-coding RNAs in cardiac regeneration
T2  - Frontiers in physiology
N2  - The adult heart has a limited capacity to replace or regenerate damaged cardiac tissue following severe myocardial injury. Thus, therapies facilitating the induction of cardiac regeneration holds great promise for the treatment of end-stage heart failure, and for pathologies invoking severe cardiac dysfunction as a result of cardiomyocyte death. Recently, a number of studies have demonstrated that cardiac regeneration can be achieved through modulation and/or reprogramming of cardiomyocyte proliferation, differentiation, and survival signaling. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are reported to play critical roles in regulating key aspects of cardiomyocyte physiologic and pathologic signaling, including the regulation of cardiac regeneration both in vitro and in vivo. In this review, we will explore and detail the current understanding of ncRNA function in cardiac regeneration, and highlight established and novel strategies for the treatment of heart failure through modulation of ncRNAs-driven cardiac regeneration.
KW  - ncRNA
KW  - miRNA
KW  - lncRNA
KW  - cardiac regeneration
KW  - cardiomyocyte proliferation
KW  - cardiac differentiation
KW  - cardiac reprogramming
KW  - cardiomyocyte apoptosis
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61126
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-611266
SN  - 1664-042X
VL  - 12
IS  - art. 650566
SP  - 1
EP  - 13
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -