TY  - JOUR
A1  - Xie, Christopher
A1  - Schäfer, Liliana
A1  - Iozzo, Renato V.
T1  - Global impact of proteoglycan science on human diseases
T2  - iScience
N2  - In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss the role of proteoglycans in selected and emerging areas of proteoglycan science, such as neurodegenerative diseases, autophagy, angiogenesis, cancer, infections and their impact on mammalian diseases.
KW  - Cell surface proteoglycans
KW  - small leucine-rich proteoglycans
KW  - angiogenesis
KW  - autophagy
KW  - SARS-CoV-2
KW  - cancer
KW  - inflammation
KW  - neurodegenerative diseases
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79154
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-791544
SN  - 2589-0042
VL  - 26
IS  - 108095
PB  - Elsevier
CY  - Amsterdam
ER  -