TY  - JOUR
A1  - Diefenhardt, Markus
A1  - Chatzikonstantinou, Georgios
A1  - Meissner, Markus
A1  - Köhn, Janett
A1  - Scherf, Christian
A1  - Trommel, Martin
A1  - Licher, Jörg
A1  - Ramm, Ulla
A1  - Rödel, Claus
A1  - Tselis, Nikolaos
T1  - HDR brachytherapy with individual epithetic molds for facial skin cancer: techniques and first clinical experience
T2  - International journal of dermatology
N2  - Background: Facial skin cancer lesions in close proximity to critical organs require further development of radiotherapeutic techniques for highly conformal treatment, especially when treating elderly frail patients. We report on our treatment technique and first clinical experience for patients with perinasal/periorbital skin cancer treated with individualized epithetic mold high-dose-rate brachytherapy (BRT).
Methods: From January 2019, patients with complex shaped or unfavorably located skin cancer not eligible for surgery or external beam radiotherapy (RT) were screened for mold-based BRT. Six patients were identified. Toxicity and clinical response were documented during therapy and posttreatment follow-up.
Results: Median patient age was 80 years (74–92 years). Median prescription dose was 42 Gy (range, 33–44 Gy) delivered in once-daily fractions of 3 or 4 Gy. Two patients had treatment interruptions caused by acute conjunctivitis grade 2 and a nontreatment-related cardiac event, respectively. At a median follow-up of 335 days (96–628 days), no ≥ grade 2 late toxicity was documented with all patients showing complete clinical response.
Conclusions: High-dose-rate BRT with individualized epithetic molds for perinasal/periorbital skin cancer is a well-tolerated and safe treatment option for patients not eligible for primary surgery or definitive external beam RT because of comorbidities or tumor location.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62100
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621001
SN  - 1365-4632
N1  - Open Access funding enabled and organized by Projekt DEAL
VL  - 60
IS  - 6
SP  - 717
EP  - 723
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -