TY  - JOUR
A1  - Rahighi, Simin
A1  - Đikić, Ivan
T1  - Selectivity of the ubiquitin-binding modules
T2  - FEBS Letters
N2  - Ubiquitin-binding modules are constituents of cellular proteins that mediate the effects of ubiquitylation by making transient, non-covalent interactions with ubiquitin molecules. While some ubiquitin-binding modules bind single ubiquitin moieties, others are selective for specific ubiquitin chains of different linkage types and lengths. In recent years, functions of ubiquitin chains that are polymerized through their Lys or N-terminal Met (i.e. linear chains) residues have been linked to a variety of cellular processes. Selectivity of ubiquitin-binding modules for different ubiquitin chain types appears as a key to the distinct regulatory consequences during protein quality control pathways, receptor endocytosis, gene transcription, signaling via the NF-κB pathway, and autophagy.
KW  - Ubiquitin-binding module
KW  - Ubiquitin signaling
KW  - Ubiquitylation
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76697
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-766974
SN  - 0014-5793
VL  - 586
IS  - 17
SP  - 2705
EP  - 2710
PB  - Elsevier
CY  - Amsterdam
ER  -