TY  - JOUR
A1  - Schramm, Fabian
A1  - Schäfer, Liliana
A1  - Wygrecka, Małgorzata
T1  - EGFR signaling in lung fibrosis
T2  - Cells
N2  - In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and their ligands in the maladaptive remodeling of lung tissue, with special emphasis on idiopathic pulmonary fibrosis (IPF). Here we will focus on the pathways and cellular processes contributing to epithelial–mesenchymal miscommunication seen in this pathology. We will also provide an overview of the in vivo studies addressing the efficacy of different ErbB signaling inhibitors in experimental models of lung injury and highlight how such studies may contribute to our understanding of ErbB biology in the lung. Finally, we will discuss what we learned from clinical applications of the ErbB1 signaling inhibitors in cancer in order to advance clinical trials in IPF.
KW  - epidermal growth factor
KW  - epidermal growth factor receptor
KW  - ErbB-signaling
KW  - pulmonary fibrosis
KW  - idiopathic pulmonary fibrosis
KW  - lung fibrosis
KW  - tyrosine kinase inhibitor
KW  - TGF-α
KW  - TGF-β
KW  - amphiregulin
KW  - neuregulin 1
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83134
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-831343
SN  - 2073-4409
N1  - Funding: German Center for Lung Research ; 82 DZL 005A1
VL  - 11
IS  - 6, art. 986
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel
ER  -