TY  - JOUR
A1  - Hutton, Chloe
A1  - De Vita, Enrico
A1  - Ashburner, John
A1  - Deichmann, Ralf
A1  - Turner, Robert
T1  - Voxel-based cortical thickness measurements in MRI
T2  - NeuroImage
N2  - The thickness of the cerebral cortex can provide valuable information about normal and abnormal neuroanatomy. High resolution MRI together with powerful image processing techniques has made it possible to perform these measurements automatically over the whole brain. Here we present a method for automatically generating voxel-based cortical thickness (VBCT) maps. This technique results in maps where each voxel in the grey matter is assigned a thickness value. Sub-voxel measurements of thickness are possible using sub-sampling and interpolation of the image information. The method is applied to repeated MRI scans of a single subject from two MRI scanners to demonstrate its robustness and reproducibility. A simulated data set is used to show that small focal differences in thickness between two groups of subjects can be detected. We propose that the analysis of VBCT maps can provide results that are complementary to other anatomical analyses such as voxel-based morphometry.
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76382
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-763821
SN  - 1053-8119
VL  - 40
IS  - 4
SP  - 1701
EP  - 1710
PB  - Elsevier
CY  - Amsterdam
ER  -