TY  - JOUR
A1  - Tscheliessnig, Rupert
A1  - Zörnig, Martin
A1  - Herzig, Eva M.
A1  - Lückerath, Katharina Maria
A1  - Altrichter, Jens
A1  - Kemter, Kristina
A1  - Paunel-Görgülü, Adnana-Nicoleta
A1  - Lögters, Tim Tobias
A1  - Windolf, Joachim
A1  - Pabisch, Silvia
A1  - Cinatl, Jindrich
A1  - Rabenau, Holger
A1  - Jungbauer, Alois
A1  - Müller-Buschbaum, Peter
A1  - Scholz, Martin
A1  - Koch, Joachim
T1  - Nano-coating protects biofunctional materials
T2  - Materials today
N2  - The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75958
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-759588
SN  - 1369-7021
SN  - 1873-4103
VL  - 15
IS  - 9
SP  - 394
EP  - 404
PB  - Elsevier
CY  - Amsterdam
ER  -