TY  - JOUR
A1  - Rappl, Peter
A1  - Brüne, Bernhard
A1  - Schmid, Tobias
T1  - Role of tristetraprolin in the resolution of inflammation
T2  - Biology
N2  - Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate manner to prevent excessive tissue damage due to the highly reactive inflammatory environment. Initiation of inflammatory responses was proposed to be regulated predominantly at a transcriptional level, whereas post-transcriptional modes of regulation appear to be crucial for resolution of inflammation. The RNA-binding protein tristetraprolin (TTP) interacts with AU-rich elements in the 3′ untranslated region of mRNAs, recruits deadenylase complexes and thereby facilitates degradation of its targets. As TTP regulates the mRNA stability of numerous inflammatory mediators, it was put forward as a crucial post-transcriptional regulator of inflammation. Here, we summarize the current understanding of the function of TTP with a specific focus on its role in adding to resolution of inflammation.
KW  - RNA-binding protein
KW  - AU-rich element
KW  - post-transcriptional regulation
KW  - mRNA stability
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57790
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-577900
SN  - 2079-7737
N1  - © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/
VL  - 10
IS  - 66
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -