TY  - JOUR
A1  - Jüngel, Eva
A1  - Erb, Holger Hans Hermann
A1  - Haferkamp, Axel
A1  - Rutz, Jochen
A1  - Chun, Felix
A1  - Blaheta, Roman A.
T1  - Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors
T2  - Cancer Letters
N2  - Due to an increased understanding of molecular biology and the genomics of cancer, new and potent agents have been approved by the Food and Drug Administration (FDA) to fight this disease. However, all of these drugs cause severe side effects and resistance inevitably develops, re-activating tumor growth and dissemination. For this reason, patients turn to natural compounds as alternative or complementary treatment options, since it has been found that natural plant products may block, inhibit, or reverse cancer development. The present review focusses on the role of the natural compound sulforaphane (SFN) as an anti-tumor agent in urologic cancer. SFN is a natural compound found in cruciferous vegetables from the Brassicaceae family such as broccoli, cauliflower and cabbage. Several epidemiologic and clinical studies have documented chemopreventive properties of SFN, making it an interesting candidate for additive cancer treatment. SFN shows remarkable anti-tumor effects in vitro and in vivo without exerting toxicity. The review summarizes the current understanding of SFN and provides insights into its molecular mode of action with particular emphasis on epigenetic tumor control.
KW  - Sulphoraphane
KW  - Dietary HDAC inhibitor
KW  - Chemoprevention
KW  - Urologic tumors
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77441
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-774413
SN  - 0304-3835
VL  - 435
SP  - 121
EP  - 126
PB  - Elsevier
CY  - Amsterdam
ER  -