TY  - JOUR
A1  - Leiblein, Maximilian
A1  - Winkenbach, Andreas Thomas
A1  - Koch, Elias Andreas Thomas
A1  - Schaible, Alexander
A1  - Büchner, Hubert
A1  - Marzi, Ingo
A1  - Henrich, Dirk
A1  - Nau, Christoph
T1  - Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model
T2  - European journal of trauma and emergency surgery
N2  - Purpose: The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum, the induced membrane differs significantly. However, both play a crucial role in bone regeneration. As part of a histological and radiological post-evaluation of an earlier project, we analyzed the influence of the granule size of the bone void filler Herafill® on development of periosteum regrowth in a critical size defect.
Methods: We compared three different sizes of Herafill® granules (Heraeus Medical GmbH, Wehrheim) in vivo in a rat femoral critical size defect (10 mm) treated with the induced membrane technique. After 8 weeks healing time, femurs were harvested and taken for histological and radiological analysis.
Results: A significantly increased regrowth of periosteum into the defect was found when small granules were used. Large granules showed significantly increased occurrence of bone capping. Small granules lead to significant increase in callus formation in the vicinity to the membrane.
Conclusion: The size of Herafill® granules has significant impact on the development of periosteal-like structures around the defect using Masquelet’s induced membrane technique. Small granules show significantly increased regrowth of periosteum and improved bone formation adjacent to the induced membrane.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74499
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-744992
SN  - 1863-9941
N1  - Open Access funding enabled and organized by Projekt DEAL. This project was funded in part by Heraeus Medical GmbH, Wehrheim, Germany.
VL  - 48
IS  - 1
SP  - 679
EP  - 687
PB  - Springer Medizin
CY  - Heidelberg
ER  -