TY  - JOUR
A1  - Grumati, Paolo
A1  - Đikić, Ivan
T1  - Ubiquitin signaling and autophagy
T2  - Journal of biological chemistry
N2  - Ubiquitination is a widespread post-translational modification that controls multiple steps in autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of ubiquitin chains are attached as selective labels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent degradation. Moreover, ubiquitin modification of autophagy regulatory components is essential to positively or negatively regulate autophagy flux in both non-selective and selective pathways. We review the current findings that elucidate the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impact on the development of human diseases.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77428
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-774280
SN  - 0021-9258
VL  - 293.2018
IS  - 15
SP  - 5404
EP  - 5413
PB  - American Society for Biochemistry and Molecular Biology
CY  - Bethesda, Md.
ER  -