TY  - JOUR
A1  - Klein, Daniel
A1  - Rotarska-Jagiela, Anna
A1  - Genç, Erhan
A1  - Sritharan, Sharmili
A1  - Mohr, Harald
A1  - Roux, Frederic
A1  - Han, Cheol E.
A1  - Kaiser, Marcus
A1  - Singer, Wolf
A1  - Uhlhaas, Peter J.
T1  - Adolescent brain maturation and cortical folding : evidence for reductions in gyrification
T2  - PLoS One
N2  - Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32841
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-328419
SN  - 1932-6203
N1  - Copyright: © 2014 Klein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (1):e84914
PB  - PLoS
CY  - Lawrence, Kan.
ER  -