TY  - JOUR
A1  - Kolb, Jasmine
A1  - Anders-Maurer, Marie
A1  - Müller, Tanja
A1  - Hau, Ann-Christin
A1  - Grebbin, Britta Moyo
A1  - Kallenborn-Gerhardt, Wiebke
A1  - Behrends, Christian
A1  - Schulte, Dorothea
T1  - Arginine methylation regulates MEIS2 nuclear localization to promote neuronal differentiation of adult SVZ progenitors
T2  - Stem cell reports
N2  - Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined. Here, we report that MEIS2, an essential regulator of adult SVZ neurogenesis, is subject to posttranslational regulation in the SVZ olfactory bulb neurogenic system. Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. Our results describe a form of posttranscriptional modulation of adult SVZ neurogenesis whereby an extrinsic signal fine-tunes neurogenesis through posttranslational modification of a transcriptional regulator of cell fate.
KW  - CRM1
KW  - MEIS2
KW  - PBX1
KW  - TALE-homdomain protein
KW  - controlled nuclear import
KW  - neurogenesis
KW  - posttranslational modification
KW  - stem cell niche
KW  - subventricular zone
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47472
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-474723
SN  - 2213-6711
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 10
IS  - 4
SP  - 1184
EP  - 1192
PB  - Cell Press ; Elsevier
CY  - Maryland Heights, MO ; [New York, NY]
ER  -