TY  - INPR
A1  - Shalamova, Lyudmila
A1  - Felgenhauer, Ulrike
A1  - Schaubmar, Andreas R.
A1  - Büttner, Kathrin
A1  - Widera, Marek
A1  - Ciesek, Sandra
A1  - Weber, Friedemann
T1  - Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
T2  - bioRxiv
N2  - The new variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype strain (B.1) with respect to their interactions with the antiviral type I interferon (IFN-alpha/beta) response in infected cells. Our data indicate that Omicron has gained an elevated capability to suppress IFN-beta induction upon infection and to better withstand the antiviral state imposed by exogenously added IFN-alpha.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73001
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-730019
IS  - 2022.01.20.476754
ER  -