TY  - JOUR
A1  - Minciacchi, Valentina R.
A1  - Kumar, Rahul
A1  - Krause, Daniela Sandra
T1  - Chronic myeloid leukemia: a model disease of the past, present and future
T2  - Cells
N2  - Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
KW  - chronic myeloid leukemia
KW  - history
KW  - targeted therapy
KW  - metabolism
KW  - bone marrow microenvironment
KW  - combination therapies
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57703
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-577036
SN  - 2073-4409
VL  - 10
IS  - Article 117
PB  - MDPI
CY  - Basel
ER  -