TY  - JOUR
A1  - Harapan, Harapan
A1  - Mudatsir, Mudatsir
A1  - Yufika, Amanda
A1  - Nawawi, Yusuf
A1  - Wahyuniati, Nur
A1  - Anwar, Samsul
A1  - Yusri, Fitria
A1  - Haryanti, Novi
A1  - Wijayanti, Nanda Putri
A1  - Rizal, Rizal
A1  - Fitriani, Devi
A1  - Maulida, Nurul Fadhliati
A1  - Syahriza, Muhammad
A1  - Ikram, Ikram
A1  - Fandoko, Try Purwo
A1  - Syahadah, Muniati
A1  - Asrizal, Febrivan Wahyu
A1  - Jamil, Kurnia
A1  - Rajamoorthy, Yogambigai
A1  - Wagner, Abram Luther
A1  - Groneberg, Jan David Alexander
A1  - Kuch, Ulrich
A1  - Müller, Ruth
A1  - Sasmono, R. Tedjo
A1  - Imrie, Allison
T1  - Willingness to participate and associated factors in a Zika vaccine trial in Indonesia : a cross-sectional study
T2  - Viruses
N2  - One of the crucial steps during trials for Zika and other vaccines is to recruit participants and to understand how participants’ attitudes and sociodemographic characteristics affect willingness to participate (WTP). This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to participate in a Zika vaccine trial without a financial compensation. In the multivariate analysis, WTP was tied to an age of more than 50 years old, compared to 20–29 years (odds ratio (OR): 5.0; 95% confidence interval (CI): 2.37–10.53), to being female (OR: 2.20; 95% CI: 1.11–4.37), and to having heard about Zika (OR: 2.41; 95% CI: 1.59–3.65). Participants’ WTP increased gradually with higher financial compensation. The rate of WTP increased to 62.3% at the highest offer (US$ 350.4), and those who were still unwilling to participate (37.7%) had a poorer attitude towards childhood vaccination. This study highlights that pre-existing knowledge about Zika and attitudes towards childhood vaccination are important in determining community members being willing to participate in a vaccine trial. Financial incentives are still an important factor to enhance participant recruitment during a vaccine trial.
KW  - Zika
KW  - Zika vaccine
KW  - vaccine trial
KW  - willingness to participate
KW  - vaccine acceptance
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48489
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-484892
SN  - 1999-4915
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 10
IS  - 11, Art. 648
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -