TY  - JOUR
A1  - Hillerer, Katharina
A1  - Slattery, David A.
A1  - Pletzer, Belinda
T1  - Neurobiological mechanisms underlying sex-related differences in stress-related disorders: effects of neuroactive steroids on the hippocampus
T2  - Frontiers in neuroendocrinology
N2  - Men and women differ in their vulnerability to a variety of stress-related illnesses, but the underlying neurobiological mechanisms are not well understood. This is likely due to a comparative dearth of neurobiological studies that assess male and female rodents at the same time, while human neuroimaging studies often don’t model sex as a variable of interest. These sex differences are often attributed to the actions of sex hormones, i.e. estrogens, progestogens and androgens. In this review, we summarize the results on sex hormone actions in the hippocampus and seek to bridge the gap between animal models and findings in humans. However, while effects of sex hormones on the hippocampus are largely consistent in animals and humans, methodological differences challenge the comparability of animal and human studies on stress effects. We summarise our current understanding of the neurobiological mechanisms that underlie sex-related differences in behavior and discuss implications for stress-related illnesses.
KW  - Stress
KW  - Sex differences
KW  - Cognition
KW  - Translational
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51096
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-510968
SN  - 1095-6808
SN  - 0091-3022
N1  - © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
VL  - 55
IS  - Art. 100796
SP  - 1
EP  - 29
PB  - Academic Press
CY  - Orlando, Fla.
ER  -