TY  - JOUR
A1  - Kerscher, Stefan
A1  - Durstewitz, Gregor
A1  - Casaregola, Serge
A1  - Gaillardin, Claude
A1  - Brandt, Ulrich
T1  - The complete mitochondrial genome of Yarrowia lipolytica
T2  - Comparative and functional genomics
N2  - We here report the complete nucleotide sequence of the 47.9 kb mitochondrial (mt) genome from the obligate aerobic yeast Yarrowia lipolytica. It encodes, all on the same strand, seven subunits of NADH: ubiquinone oxidoreductase (ND1-6, ND4L), apocytochrome b (COB), three subunits of cytochrome oxidase (COX1, 2, 3), three subunits of ATP synthetase (ATP6, 8 and 9), small and large ribosomal RNAs and an incomplete set of tRNAs. The Y. lipolytica mt genome is very similar to the Hansenula wingei mt genome, as judged from blocks of conserved gene order and from sequence homology. The extra DNA in the Y. lipolytica mt genome consists of 17 group 1 introns and stretches of A+Trich sequence, interspersed with potentially transposable GC clusters. The usual mould mt genetic code is used. Interestingly, there is no tRNA able to read CGN (arginine) codons. CGN codons could not be found in exonic open reading frames, whereas they do occur in intronic open reading frames. However, several of the intronic open reading frames have accumulated mutations and must be regarded as pseudogenes. We propose that this may have been triggered by the presence of untranslatable CGN codons. This sequence is available under EMBL Accession No. AJ307410.
KW  - Yarrowia lipolytica mitochondrial genome complex I NADH: ubiquinoneoxidoreductase
KW  - NADH dehydrogenase
KW  - tRNA
KW  - CGN codon
KW  - intronic ORF
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6014
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-60275
SN  - 1531-6912
SN  - 1532-6268
N1  - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2
IS  - 2
SP  - 80
EP  - 90
PB  - Wiley InterScience ; Hindawi
CY  - Chichester [u. a.] ; New York, NY
ER  -