TY  - JOUR
A1  - Grent-'t-Jong, Tineke
A1  - Groß, Joachim
A1  - Goense, Jozien
A1  - Wibral, Michael
A1  - Gajwani, Ruchika
A1  - Gumley, Andrew I.
A1  - Lawrie, Stephen M.
A1  - Schwannauer, Matthias
A1  - Schultze-Lutter, Frauke
A1  - Schröder, Tobias Navarro
A1  - Köthe, Dagmar
A1  - Leweke, F. Markus
A1  - Singer, Wolf
A1  - Uhlhaas, Peter J.
T1  - Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
T2  - eLife
N2  - We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
KW  - Research Article
KW  - Neuroscience
KW  - Schizophrenia
KW  - E/I-Balance
KW  - Gamma-Band Activity
KW  - human
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47691
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-476915
SN  - 2050-084X
N1  - Copyright Grent-’t-Jong et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
VL  - 7
IS  - e37799
SP  - 1
EP  - 19
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -