TY  - JOUR
A1  - Gunne, Sandra
A1  - Heinicke, Ulrike
A1  - Parnham, Michael J.
A1  - Laux, Volker
A1  - Zacharowski, Kai
A1  - Knethen, Andreas von
T1  - Nrf2 - a molecular target for sepsis Ppatients in critical care
T2  - Biomolecules
N2  - The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive oxygen species (ROS) seems obvious. In line with this, data obtained in cell culture experiments and preclinical settings have shown that Nrf2 is important in regulating target genes that are necessary to ensure cellular redox balance. Additionally, Nrf2 is involved in the induction of phase II drug metabolizing enzymes, which are important both in degrading and converting drugs into active forms, and into putative carcinogens. Therefore, Nrf2 has also been implicated in tumorigenesis. This must be kept in mind when new therapy approaches are planned for the treatment of sepsis. Therefore, this review highlights the function of Nrf2 in sepsis with a special focus on the translation of rodent-based results into sepsis patients in the intensive care unit (ICU).
KW  - sepsis
KW  - inflammation
KW  - resolution
KW  - detoxification
KW  - antioxidant defense
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57224
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-572242
SN  - 2218-273X
VL  - 10
IS  - Article 1688
PB  - MDPI
CY  - Basel
ER  -