TY  - JOUR
A1  - Fulda, Simone
T1  - Regulation of cell death in cancer - possible implications for immunotherapy
T2  - Frontiers in oncology
N2  - Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future.
KW  - cell death
KW  - childhood cancer
KW  - immunotherapy
KW  - signal transduction
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27410
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-274105
SN  - 2234-943X
N1  - Copyright © 2013 Fulda. This is an open-access article distributed under the terms of the Creative Commons Commercial License http://creativecommons.org/licenses/by/3.0/ , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
VL  - 3
IS  - Article 29
PB  - Frontiers Media
CY  - Lausanne
ER  -