TY  - JOUR
A1  - Scheuing, Nicole
A1  - Holl, Reinhard W.
A1  - Dockter, Gerd
A1  - Hermann, Julia M.
A1  - Junge, Sibylle
A1  - Koerner-Rettberg, Cordula
A1  - Nährlich, Lutz
A1  - Smaczny, Christina
A1  - Staab, Doris
A1  - Thalhammer, Gabriela
A1  - Koningsbruggen-Rietschel, Silke van
A1  - Ballmann, Manfred
T1  - High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis : a multicenter screening study
T2  - PLoS One
N2  - Background: In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective of this short report was to evaluate within-patient variability of oral glucose tolerance.
Methods: In total, 4,643 standardized oral glucose tolerance tests of 1,128 cystic fibrosis patients (median age at first test: 15.5 [11.5; 21.5] years, 48.8% females) were studied. Patients included were clinically stable, non-pregnant, and had at least two oral glucose tolerance tests, with no prior lung transplantation or systemic steroid therapy. Transition frequency from any one test to the subsequent test was analyzed and within-patient coefficients of variation were calculated for fasting and two hour blood glucose values. All statistical analysis was implemented with SAS 9.4.
Results: A diabetic glucose tolerance was confirmed in 41.2% by the subsequent test. A regression to normal glucose tolerance at the subsequent test was observed in 21.7% and to impaired fasting glucose, impaired glucose tolerance or both in 15.2%, 12.0% or 9.9%. The average within-patient coefficient of variation for fasting blood glucose was 11.1% and for two hour blood glucose 25.3%.
Conclusion: In the cystic fibrosis patients studied, a highly variable glucose tolerance was observed. Compared to the general population, variability of two hour blood glucose was 1.5 to 1.8-fold higher.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/35338
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-353382
SN  - 1932-6203
N1  - Copyright: © 2014 Scheuing et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (11):e112578
PB  - PLoS
CY  - Lawrence, Kan.
ER  -