TY  - JOUR
A1  - Linder, Benedikt
A1  - Kögel, Donat
T1  - Autophagy in cancer cell death
T2  - Biology
N2  - Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of autophagy in cell survival and cell death decisions is highly dependent on its extent, duration, and on the respective cellular context. An alternative pro-death function of autophagy has been consistently observed in different settings, in particular, in developmental cell death of lower organisms and in drug-induced cancer cell death. This cell death is referred to as autophagic cell death (ACD) or autophagy-dependent cell death (ADCD), a type of cellular demise that may act as a backup cell death program in apoptosis-deficient tumors. This pro-death function of autophagy may be exerted either via non-selective bulk autophagy or excessive (lethal) removal of mitochondria via selective mitophagy, opening new avenues for the therapeutic exploitation of autophagy/mitophagy in cancer treatment.
KW  - autophagy
KW  - cell death
KW  - cancer
KW  - gossypol
KW  - AT-101
KW  - mitophagy
KW  - mitochondria
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51837
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-518371
SN  - 2079-7737
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 4, Art. 82
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  -