TY  - JOUR
A1  - Ullrich, Evelyn
A1  - Salzmann-Manrique, Emilia
A1  - Bakhtiar, Shahrzad
A1  - Bremm, Melanie
A1  - Gerstner, Stephanie
A1  - Herrmann, Eva
A1  - Bader, Peter
A1  - Hoffmann, Petra
A1  - Holler, Ernst
A1  - Edinger, Matthias
A1  - Wolff, Daniel
T1  - Relation between acute GVHD and NK cell subset reconstitution following allogeneic stem cell transplantation
T2  - Frontiers in immunology
N2  - One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known capability to induce GVL without GVHD. Here, in this study, we investigate the association between the incidence and severity of acute graft-versus-host disease (aGVHD) and the early reconstitution of NK cell subsets following allo-SCT. We analyzed 342 samples from 107 patients using flow cytometry, with a focus on immature CD56high and mature cytotoxic CD56dim NK cells. Longitudinal analysis of immune reconstitution after allo-SCT showed that the incidence of aGVHD was associated with a delayed expansion of the entire NK cell population, in particular the CD56high subset. Notably, the disturbed reconstitution of the CD56high NK cells also correlated with the severity of aGVHD.
KW  - NK cell
KW  - NK cell subset
KW  - GVHD
KW  - SCT
KW  - immune reconstitution
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51726
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-517268
SN  - 1664-3224
N1  - Copyright: © 2016 Ullrich, Salzmann-Manrique, Bakhtiar, Bremm, Gerstner, Herrmann, Bader, Hoffmann, Holler, Edinger and Wolff. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 7
IS  - Art. 595
SP  - 1
EP  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  -