TY  - JOUR
A1  - Neef, Vanessa
A1  - Vo, Linda
A1  - Herrmann, Eva
A1  - Triphaus, Chris
A1  - Judd, Leonie
A1  - Winter, Andreas
A1  - Zacharowski, Kai
A1  - Choorapoikayil, Suma
A1  - Meybohm, Patrick
T1  - The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery – an observational study in a patient blood management centre
T2  - Anaesthesiology intensive therapy
N2  - Introduction: Cell salvage (CS) is an integral part of patient blood management (PBM) and aims to reduce allogeneic red blood cell (RBC) transfusion.
Material and methods: This observational study analysed patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB) between November 2015 and October 2018. Patients were divided into a CS group (patients receiving CS) and a control group (no CS). Primary endpoints were the number of patients exposed to allogeneic RBC transfusions and the number of RBC units transfused per patient.
Results: A total of 704 patients undergoing cardiac surgery were analysed, of whom 338 underwent surgery with CS (CS group) and 366 were without CS (control group). Intraoperatively, 152 patients (45%) were exposed to allogeneic RBC transfusions in the CS group and 93 patients (25%) in the control group (P < 0.001). Considering the amount of intraoperative blood loss, regression analysis revealed a significant association between blood loss and increased use of RBC units in patients of the control compared to the CS group (1000 mL: 1.0 vs. 0.6 RBC units; 2000 mL: 2.2 vs. 1.1 RBC units; 3000 mL: 3.4 vs. 1.6 RBC units). Thus, CS was significantly associated with a reduced number of allogeneic RBCs by 40% for 1000 mL, 49% for 2000 mL, and 52% for 3000 mL of blood loss compared to patients without CS.
Conclusions: Cell salvage was significantly associated with a reduced number of allogeneic RBC transfusions. It supports the beneficial effect of CS in cardiac surgical patients as an individual measure in a comprehensive PBM program.
KW  - cell salvage
KW  - cardiac surgery
KW  - patient blood management
KW  - transfusion
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62943
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-629437
SN  - 1731-2531
SN  - 1642-5758
N1  - Implementation of the Patient Blood Management program was supported by B. Braun Melsungen, CSL Behring, Fresenius Kabi, and Vifor Pharma.
VL  - 53
IS  - 1
SP  - 1
EP  - 9
PB  - Medigo
CY  - Warszawa
ER  -