TY  - CHAP
A1  - Mavroidis, Panayiotis
A1  - Baltas, Dimos
A1  - Lind, Bengt K.
A1  - Papanikolaou, Nikos
A2  - Spiess, Philippe E.
T1  - Use of radiobiological modeling in treatment plan evaluation and optimization of prostate cancer radiotherapy
T2  - Prostate cancer - diagnostic and therapeutic advances
N2  - There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints. All the already mentioned evaluation tools are dosimetric only without taking into account the radiobiological characteristics of tumors or OARs. It has been demonstrated that although competing treatment plans might have similar mean, maximum or minimum doses they may have significantly different clinical outcomes (Mavroidis et al. 2001). For performing a more complete treatment plan evaluation and comparison the complication-free tumor control probability (P+) and the biologically effective uniform dose (D ) have been proposed (Källman et al. 1992a, Mavroidis et al. 2000). The D concept denotes that any two dose distributions within a target or OAR are equivalent if they produce the same probability for tumor control or normal tissue complication, respectively (Mavroidis et al. 2001)...
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31710
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-317101
SN  - 978-953-307-319-4
N1  - Published: under CC BY 3.0 license
SP  - 237
EP  - 260
PB  - InTech
CY  - [Erscheinungsort nicht ermittelbar]
ER  -