TY  - JOUR
A1  - Schäfer, Richard
A1  - Mueller, Lars
A1  - Buecheler, Reinhild
A1  - Proksch, Barbara
A1  - Schwab, Matthias
A1  - Gleiter, Christoph H.
A1  - Danielyan, Lusine
T1  - Interplay between endothelin and erythropoietin in astroglia : the role in protection against hypoxia
T2  - International journal of molecular sciences
N2  - We show that, under in vitro conditions, the vulnerability of astroglia to hypoxia is reflected by alterations in endothelin (ET)-1 release and capacity of erythropoietin (EPO) to regulate ET-1 levels. Exposure of cells to 24 h hypoxia did not induce changes in ET-1 release, while 48–72 h hypoxia resulted in increase of ET-1 release from astrocytes that could be abolished by EPO. The endothelin receptor type A (ETA) antagonist BQ123 increased extracellular levels of ET-1 in human fetal astroglial cell line (SV-FHAS). The survival and proliferation of rat primary astrocytes, neural precursors, and neurons upon hypoxic conditions were increased upon administration of BQ123. Hypoxic injury and aging affected the interaction between the EPO and ET systems. Under hypoxia EPO decreased ET-1 release from astrocytes, while ETA receptor blockade enhanced the expression of EPO mRNA and EPO receptor in culture-aged rat astroglia. The blockade of ETA receptor can increase the availability of ET-1 to the ETB receptor and can potentiate the neuroprotective effects of EPO. Thus, the new therapeutic use of combined administration of EPO and ETA receptor antagonists during hypoxia-associated neurodegenerative disorders of the central nervous system (CNS) can be suggested.
KW  - endothelin
KW  - erythropoietin
KW  - astroglia
KW  - neuroprotection
KW  - hypoxia
KW  - endothelin receptor type A antagonist
KW  - aging
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37056
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-370568
SN  - 1422-0067
N1  - © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 15
IS  - 2
SP  - 2858
EP  - 2875
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -