TY  - JOUR
A1  - Leisegang, Matthias
T1  - LET's sponge : how the lncRNA PFL promotes cardiac fibrosis
T2  - Theranostics
N2  - Compared to their protein-coding counterparts, almost nothing is known about the role of long noncoding RNAs (lncRNAs) in cardiac fibrosis. In the current report, Liang and Pan et al. characterized the pro-fibrotic lncRNA PFL in respect to cardiac fibrosis in mice. PFL was upregulated in the hearts of mice after myocardial infarction and in fibrotic cardiac fibroblasts. Moreover, PFL competitively sponged the cardio-protective miRNA let-7d in cardiac fibroblasts. Knockdown of platelet activating factor receptor (PTAFR) was shown to affect the pro-fibrotic collagen production mediated by PFL. PTAFR overexpression also led to collagen production and RNA abundance of PTAFR was also regulated by miRNA let-7d. Therefore, the PFL/PTAFR/let-7d-dependent gene regulatory mechanism proposed by the authors manifests the hypothesis of competing endogenous RNAs to cardiac fibrosis.
KW  - LncRNA
KW  - PFL
KW  - miRNA
KW  - ceRNA
KW  - Cardiac Fibrosis
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45570
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-455707
SN  - 1838-7640
N1  - © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
VL  - 8
IS  - 4
SP  - 874
EP  - 877
PB  - Ivyspring
CY  - Wyoming, NSW
ER  -