TY  - JOUR
A1  - Casadellà, Maria
A1  - Cozzi-Lepri, Alessandro
A1  - Phillips, Andrew
A1  - Noguera-Julian, Marc
A1  - Bickel, Markus
A1  - Sedlacek, Dalibor
A1  - Zilmer, Kai
A1  - Clotet, Bonaventura
A1  - Lundgren, Jens D.
A1  - Paredes, Roger
T1  - Plasma HIV-1 tropism and the risk of short-term clinical progression to AIDS or death
T2  - PLoS one
N2  - Objective: To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management.
Design: Nested case-control study within the EuroSIDA cohort.
Methods: Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling.
Results: The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups.
Conclusions: The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42889
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-428890
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271314
SN  - 1932-6203
N1  - Copyright: © 2017 Casadellà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 12
IS  - (1): e0166613
SP  - 1
EP  - 14
PB  - PLoS
CY  - Lawrence, Kan.
ER  -