TY  - JOUR
A1  - Bürger, Claudia
T1  - Epidermal mTORC1 signaling contributes to the pathogenesis of psoriasis and could serve as a therapeutic target
T2  - Frontiers in immunology
N2  - Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as therapeutic targets is still scarce. However, recent efforts to understand the deregulated signal transduction pathways have led to the development of small molecule inhibitors e.g., tofacitinib targeting the Jak/Stat cascade that opens additional therapeutic options. Recently, the PI3-K/Akt/mTOR signaling pathway has emerged as an important player in the control of epidermal homeostasis. This review summarizes the current knowledge on the role of this pathway in the pathogenesis of psoriasis, especially the epidermal manifestation of the disease and discusses current approaches to target the pathway therapeutically.
KW  - psoriasis
KW  - mTORC1
KW  - keratinocytes
KW  - rapamycin
KW  - topical agent
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/49280
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-492801
SN  - 1664-3224
N1  - Copyright © 2018 Buerger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 9
IS  - Art. 2786
SP  - 1
EP  - 7
PB  - Frontiers Media
CY  - Lausanne
ER  -