TY  - JOUR
A1  - Möller, Burkhard
A1  - Kessler, Uta
A1  - Rehart, Stefan
A1  - Kalina, Uwe
A1  - Ottmann, Oliver G.
A1  - Kaltwasser, Joachim Peter
A1  - Hoelzer, Dieter
A1  - Kukoc-Zivojnov, Natasa
T1  - Expression of interleukin-18 receptor in fibroblast-like synoviocytes
T2  - Arthritis Research & Therapy
N2  - An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA. Open Access: Published: 14 November 2001 © 2002 Möller et al., licensee BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)
KW  - fibroblast
KW  - interleukin-18
KW  - receptor
KW  - rheumatoid arthritis
KW  - synoviocyte
Y1  - 2001
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/4328
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-11599
SN  - 1465-9913
SN  - 1478-6362
N1  - © 2002 Möller et al., licensee BioMed Central Ltd
VL  - 4
IS  - 2, Art. 139
SP  - 139
EP  - 144
PB  - BioMed Central
CY  - London
ER  -