TY  - JOUR
A1  - Schindler, Philipp
A1  - Heinzow, Hauke
A1  - Trebicka, Jonel
A1  - Wildgruber, Moritz
T1  - Shunt-induced hepatic encephalopathy in TIPS: current approaches and clinical challenges
T2  - Journal of Clinical Medicine
N2  - Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment tool in decompensated liver cirrhosis that has been shown to prolong transplant-free survival. Hepatic encephalopathy (HE) is a frequent complication of decompensated cirrhosis, eventually induced and/or aggravated by TIPS, that remains a clinical challenge especially in these patients. Therefore, patient selection for TIPS requires careful assessment of risk factors for HE. TIPS procedural parameters regarding stent size and invasive portosystemic pressure gradient measurements thereby have an important role. Endovascular shunt modification, in combination with a conservative medical approach, often results in a significant reduction of symptoms. This review summarizes HE molecular mechanisms and pathophysiology as well as diagnostic and therapeutic approaches targeting shunt-induced HE.
KW  - hepatic encephalopathy
KW  - transjugular portosystemic intrahepatic
KW  - shunt
KW  - liver cirrhosis
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57408
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-574081
SN  - 2077-0383
VL  - 9
IS  - Article 3784
PB  - MDPI
CY  - Basel
ER  -