TY  - JOUR
A1  - Könecke, Christian
A1  - Krueger, Andreas
T1  - MicroRNA in T-cell development and T-cell mediated acute graft-versus-host disease
T2  - Frontiers in immunology
N2  - Acute graft-versus-host disease (GvHD) is still a major cause of treatment-related mortality after allogeneic stem cell transplantation. Allo-antigen recognition of donor T cells after transplantation account for the onset and persistence of this disease. MicroRNAs (miRNAs) are molecular regulators involved in numerous processes during T-cell development, homeostasis, and activation. Thus, miRNAs also contribute to pathological T-cell function during GvHD. Given their capacity of fine-tuning T-cell function, miRNAs have emerged as promising therapeutic targets to curtail acute GvHD, but simultaneously maintain T-cell-mediated graft-versus-tumor effects. Here, we review the role of key miRNAs contributing to the pathophysiology of GvHD. We focus on those miRNAs acting in T cells and for which a role in GvHD has been established in preclinical models. Finally, we provide an outlook for clinical application of this new therapeutic target for GvHD prevention and treatment.
KW  - T cell
KW  - microRNA
KW  - graft-versus-host disease
KW  - graft-versus-tumor effect
KW  - differentiation
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47214
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-472145
SN  - 1664-3224
N1  - Copyright: © 2018 Koenecke and Krueger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 9
IS  - Art. 992
SP  - 1
EP  - 7
PB  - Frontiers Media
CY  - Lausanne
ER  -