TY  - JOUR
A1  - Theodorou, Kosta
A1  - Boon, Reinier
T1  - Endothelial cell metabolism in Atherosclerosis
T2  - Frontiers in cell and developmental biology
N2  - Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular homeostasis and disease. Atherosclerosis as well as its independent risk factors including diabetes, obesity, and aging, are hallmarked by endothelial activation and dysfunction. Metabolic pathways have emerged as key regulators of many EC functions, including angiogenesis, inflammation, and barrier function, processes which are deregulated during atherogenesis. In this review, we highlight the role of glucose, fatty acid, and amino acid metabolism in EC functions during physiological and pathological states, specifically atherosclerosis, diabetes, obesity and aging.
KW  - endothelial cells
KW  - metabolism
KW  - atherosclerosis
KW  - inflammation
KW  - hyperglycemia
KW  - hyperlipidemia
KW  - aging
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47362
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-473624
SN  - 2296-634X
N1  - Copyright © 2018 Theodorou and Boon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 6
IS  - Art. 82
SP  - 1
EP  - 9
PB  - Frontiers Media
CY  - Lausanne
ER  -