TY  - JOUR
A1  - Năstase, Mădălina-Viviana
A1  - Young, Marian F.
A1  - Schäfer, Liliana
T1  - Biglycan : a multivalent proteoglycan providing structure and signals
T2  - Journal of histochemistry & cytochemistry : JHC
N2  - Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule. Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the innate to the adaptive immune response. By clustering several types of receptors on the cell surface and orchestrating their downstream signaling events, biglycan is capable to autonomously trigger sterile inflammation and to potentiate the inflammatory response to microbial invasion. Besides operating in a broad biological context, biglycan also displays tissue-specific affinities to certain receptors and structural components, thereby playing a crucial role in bone formation, muscle integrity, and synapse stability at the neuromuscular junction. This review attempts to provide a concise summary of recent data regarding the involvement of biglycan in the regulation of inflammation and the musculoskeletal system, pointing out both a signaling and a structural role for this proteoglycan. The potential of biglycan as a novel therapeutic target or agent for the treatment of inflammatory diseases and skeletal muscular dystrophies is also addressed.
KW  - extracellular matrix
KW  - proteoglycan
KW  - Toll-like receptor
KW  - inflammasome
KW  - TGFβ
KW  - inflammation
KW  - bone
KW  - skeletal muscle
KW  - Duchenne’s muscular dystrophy
KW  - sepsis
KW  - Wnt
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31653
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-316536
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527886
SN  - 1551-5044
SN  - 0022-1554
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 60
IS  - 12
SP  - 963
EP  - 975
PB  - Histochemical Soc. ; Sage Publ.
CY  - Seattle, Wash. ; London [u. a.]
ER  -