TY  - JOUR
A1  - Thiepold, Anna-Luisa
A1  - Luger, Sebastian
A1  - Wagner, Marlies
A1  - Filmann, Natalie
A1  - Ronellenfitsch, Michael Wilfried
A1  - Harter, Patrick Nikolaus
A1  - Braczynski, Anne Kristin
A1  - Dützmann, Stephan
A1  - Hattingen, Elke
A1  - Steinbach, Joachim Peter
A1  - Senft, Christian
A1  - Rieger, Johannes
A1  - Bähr, Roy Oliver
T1  - Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma
T2  - OncoTarget
N2  - Background: Hypoxia is a key driver for infiltrative growth in experimental gliomas. It has remained elusive whether tumor hypoxia in glioblastoma patients contributes to distant or diffuse recurrences. We therefore investigated the influence of perioperative cerebral ischemia on patterns of progression in glioblastoma patients.
Methods: We retrospectively screened MRI scans of 245 patients with newly diagnosed glioblastoma undergoing resection for perioperative ischemia near the resection cavity. 46 showed relevant ischemia nearby the resection cavity. A control cohort without perioperative ischemia was generated by a 1:1 matching using an algorithm based on gender, age and adjuvant treatment. Both cohorts were analyzed for patterns of progression by a blinded neuroradiologist.
Results: The percentage of diffuse or distant recurrences at first relapse was significantly higher in the cohort with perioperative ischemia (61.1%) compared to the control cohort (19.4%). The results of the control cohort matched well with historical data. The change in patterns of progression was not associated with a difference in survival.
Conclusions: This study reveals an unrecognized association of perioperative cerebral ischemia with distant or diffuse recurrence in glioblastoma. It is the first clinical study supporting the concept that hypoxia is a key driver of infiltrative tumor growth in glioblastoma patients.
KW  - glioblastoma
KW  - hypoxia
KW  - patterns of progression
KW  - perioperative ischemia
KW  - MRI
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50598
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-505984
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 6
IS  - 16
SP  - 14537
EP  - 14544
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -