TY  - JOUR
A1  - Rué-Queralt, Joan
A1  - Stevner, Angus
A1  - Tagliazucchi, Enzo
A1  - Laufs, Helmut
A1  - Kringelbach, Morten L.
A1  - Deco, Gustavo
A1  - Atasoy, Selen
T1  - Decoding brain states on the intrinsic manifold of human brain dynamics across wakefulness and sleep
T2  - Communications biology
N2  - Current state-of-the-art functional magnetic resonance imaging (fMRI) offers remarkable imaging quality and resolution, yet, the intrinsic dimensionality of brain dynamics in different states (wakefulness, light and deep sleep) remains unknown. Here we present a method to reveal the low dimensional intrinsic manifold underlying human brain dynamics, which is invariant of the high dimensional spatio-temporal representation of the neuroimaging technology. By applying this intrinsic manifold framework to fMRI data acquired in wakefulness and sleep, we reveal the nonlinear differences between wakefulness and three different sleep stages, and successfully decode these different brain states with a mean accuracy across participants of 96%. Remarkably, a further group analysis shows that the intrinsic manifolds of all participants share a common topology. Overall, our results reveal the intrinsic manifold underlying the spatiotemporal dynamics of brain activity and demonstrate how this manifold enables the decoding of different brain states such as wakefulness and various sleep stages.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63661
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636615
SN  - 2399-3642
N1  - J.R.-Q. is funded by the Fundació Catalunya—La Pedrera Masters of Excellence Fellowship. M.L.K. and S.A. are supported by the ERC Consolidator Grant CAREGIVING (no. 615539) and Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). G.D. is supported by a Spanish national research project (ref. PID2019-105772GB-I00 /AEI/10.13039/501100011033 MCIU AEI) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI).
VL  - 4
IS  - art. 854
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - London
ER  -