TY - JOUR A1 - Schwalm, Miriam A1 - Schmid, Florian A1 - Wachsmuth, Lydia A1 - Backhaus, Hendrik A1 - Kronfeld, Andrea A1 - Aedo Jury, Felipe A1 - Prouvot, Pierre-Hugues A1 - Fois, Consuelo A1 - Albers, Franziska A1 - Alst, Timo Mauritz van A1 - Faber, Cornelius A1 - Stroh, Albrecht T1 - Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves T2 - eLife N2 - Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats. The individual slow wave events were used for an event-related analysis of simultaneously acquired whole-brain BOLD fMRI. We identified BOLD responses directly related to onsets of slow calcium waves, revealing a cortex-wide BOLD correlate: the entire cortex was engaged in this specific type of slow wave activity. These findings demonstrate a direct relation of defined neurophysiological events to a specific BOLD activity pattern and were confirmed for ongoing slow wave activity by independent component and seed-based analyses. KW - Research article KW - Neuroscience KW - Slow waves KW - Bold fmri KW - Calcium recordings Y1 - 2017 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46856 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-468568 SN - 2050-084X N1 - Copyright Schwalm et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. VL - 6 IS - e27602 SP - 1 EP - 27 PB - eLife Sciences Publications CY - Cambridge ER -