TY  - JOUR
A1  - Kremer, Melanie
A1  - Suezer, Yasemin
A1  - Martinez-Fernandez, Yolanda
A1  - Münk, Carsten
A1  - Sutter, Gerd
A1  - Schnierle, Barbara
T1  - Vaccinia virus replication is not affected by APOBEC3 family members
T2  - Virology Journal
N2  - Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection. Most poxvirus genomes are relatively A/T-rich, which may indicate APOBEC3G-induced mutational pressure. In addition, poxviruses replicate exclusively in the cytoplasm where APOBEC3G is located. It was therefore tempting to analyze whether vaccinia virus replication is affected by APOBEC3G.
Results: The replication of vaccinia virus, a prototype poxvirus, was not, however, inhibited in APOBEC3G-expressing cells, nor did other members of the APOBEC3 family alter vaccinia virus replication. HIV counteracts APOBEC3G by inducing its degradation. However, Western blot analysis showed that the levels of APOBEC3G protein were not affected by vaccinia virus infection.
Conclusion: The data indicate that APOBEC3G is not a restriction factor for vaccinia virus replication nor is vaccinia virus able to degrade APOBEC3G.
Y1  - 2007
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/1031
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-44571
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635045
SN  - 1743-422X
N1  - © 2006 Kremer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 3
IS  - 86
SP  - 1
EP  - 8
PB  - BioMed Central
CY  - London
ER  -